HORDB

ID: hor002609
Uniprot ID: Q11088
Protein name: NLP-1
Gene name: nlp-1
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0001966 thigmotaxis; GO:0071244 cellular response to carbon dioxide; GO:1903745 negative regulation of nematode pharyngeal pumping
GO CC: NA

Sequence: VNLDPNSFRMSF
Length: 12(143-154)
Propeptide: MKATFVLACLLVIAAVSHADLLPKRMDANAFRMSFGKRSVSNPAEAKRMDPNAFRMSFGKRSAEQNEQANKEDKATSDKLYDDTKFEEMKRMDANAFRMSFGKRSDAHQAADDQVEYVNDDFSLPEQKRMDANAFRMSFGKRVNLDPNSFRMSFGKRSTVGYNLDARNYFVGLGRR
Signal peptide: MKATFVLACLLVIAAVSHA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: In AWC olfactory sensory neurons, required for the detection of preferred food sources.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002609_AF2.pdb

hor002609_ESM.pdb

Mass:	162298	Formula:	C63H95N17O19S
Absent amino acids:	ACEGHIKQTWY	Common amino acids:	FNS
pI:	6.34	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	4
Hydrophobicity:	-22.5	Boman Index:	-2645
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.67
Instability Index:	4503.33	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans